By taking part in research you’ll be helping us to test and developed things like new models of care, support methods and drug treatments.

All of the studies you see below have been given approval by the Health Research Authority and will be carried out by experts with clinical, research and academic backgrounds.

Evaluating the impact of minimum unit pricing in Scotland on harmful drinkers

Who this study is aimed at?

Service users who are seeing treatment services in relation their alcohol use.

Who can’t take part?

Individuals with cognitive impairment or unable to understand and speak English.

Study summary

One off interview with a researcher.

Study visits

One.

Services taking part

Sidney Street Centre, Fitzwilliam Centre

Who to contact

Dr Olawale Lagundoye

How to contact

olawale.lagundoye@shsc.nhs.uk

The Adult Autism Spectrum Cohort – UK

Who this study is aimed at?

Adults aged 16 or older with a diagnosis of ASD

Who can’t take part?

People who do not have a confirmed diagnosis of ASD

Study summary

Questionnaire for people to be included in a cohort so that researchers can learn about the lives of adults on the autism spectrum

Study visits

One off questionnaire. Participants may be contacted in the future to be asked if they would like to take part in autism-related studies.

Services taking part

Autism Service, Michael Carlisle Centre

Who to contact

See website here.

How to contact

See website above.

TIME: Take home naloxone intervention multi centre emergency setting feasibility trial

Who this study is aimed at?

People who take opioid drugs such as heroin, morphine, fentanyl and methadone, and people who are friends or family members of a person at risk of opioid overdose

Who can’t take part?

Drug service users (or friends and family members of service users) who have no experience of opioid misuse

Study summary

One off interview lasting about 30-45 minutes or one off focus group lasting about 60 minutes

Study visits

One

Services taking part

Fitzwilliam Centre

Who to contact

Zoe Black

How to contact

zoe.black@shsc.nhs.uk

TACK - Adapting and testing a technology supported and solution-focused intervention (DIALOG+) for people with chronic depression

Who this study is aimed at?

People who have symptoms of depression or non-psychotic low mood with a duration of illness of at least 2 years and are receiving treatment from an NHS mental health service with regular contact with clinicians

Who can’t take part?

People who have a primary diagnosis of a substance misuse problem, a diagnosis of a mental disorder eg Alzheimer’s, current inpatients on a psychiatric ward.  People who do not currently have clinical contact with a mental health professional

Study summary

This research aims to develop a new approach to help people with chronic depression. Researchers have developed an intervention called “DIALOG+” which helped people with schizophrenia. DIALOG+ involved mental health staff using a tablet computer to ask about satisfaction with different areas of life and then working together to find solutions to concerns raised. After using DIALOG+, service users were more satisfied with life and had fewer symptoms. Service users and staff found the approach helpful and it saved the NHS money.

The second phase of the TACK programme is looking at the effectiveness of DIALOG+ for people with chronic depression on improving quality of life and clinical outcomes (such as depression symptoms). The intervention will be tested in routine meetings across six sites in England.  Researchers will also evaluate how cost-effective the intervention is within the NHS.  They will also determine what works well or not so well in order to improve training materials and resources for staff.

Study visits

Six months of monthly sessions, followed by six months of booster sessions, to be done at the same time as clinical appointments

Services taking part

Northlands Community Health Centre, Edmund Road, East Glade Centre

Who to contact

Matthew Mills, Shonagh Scott

How to contact

matthew.mills@shsc.nhs.uk, shonagh.scott@shsc.nhs.uk

Find out more

Find out more information here.

PPiP2: Prevalence of neuronal cell surface antibodies in patients with psychotic illness

Who this study is aimed at?

Service users aged 18-70 with symptoms of psychosis for longer than two weeks but less than two years

Who can’t take part?

Service users who have had psychotic symptoms for longer than two years

Study summary

Staff will collect a small sample of blood from you and other people with psychosis symptoms from across the country.  They will also collect some information about your symptoms and background.  If your blood test then shows that your immune system is not working properly they will discuss this with you. Researchers are exploring a possible treatment in a separate study called SINAPPS2 and you may be able to take part in this study.

Study visits

One visit of approximately 15 minutes

Services taking part

Limbrick Health Centre

Who to contact

Dr Raihan Talukdar, Alex Carey

How to contact

raihan.talukdar@shsc.nhs.uk, alex.carey@shsc.nhs.uk 

Find out more

Find out more information here.

Exploring Unusual Feelings

Who this study is aimed at?

Patients diagnosed with non-affective psychosis (i.e. schizophrenia, schizoaffective disorder, delusional disorder, psychosis not otherwise specified).

Who can’t take part?

  • Insufficient English to understand and complete the questionnaires.
  • Affective psychosis diagnosis (i.e. Psychotic Depression, Bipolar Disorder).

Study summary

This study is a questionnaire study where 1000 patients with non-affective psychosis will answer a pack of 10 questionnaires (approx. 30 minutes) once.

Who to contact

Elissa Thompson, Nurse Researcher at Research Development Unit, Sheffield Health and Social Care

How to contact

Elissa.Thompson@shsc.nhs.uk

The Impact of Environment on the Use of De-Escalation and Seclusion on Psychiatric Wards (The EnDoRSe Study)

Who this study is aimed at?

We would like to interview patients who have experienced either seclusion or restraint. This will give us valuable information about your experiences of the ward and what you think may have led to these events.

Who can’t take part?

People who have not been an in-patient on a Psychiatric ward

Study summary

How do environmental factors contribute to increases and decreases in use of seclusion and de-escalation in psychiatric inpatient settings, and the experiences of patients and staff?

Study visits

A researcher will visit you on the ward and introduce themselves to you, and answer any questions you may have about the research. If you decide that you would like to take part, then the researcher will help you to complete a consent form. The conversation will last for about an hour and you will be free to end it at any time, or refuse to answer any questions which you do not want to answer.

Who to contact

Dr. Hamid Alhaj

How to contact

Tel: 0114 226 1588

Email: h.alhaj@sheffield.ac.uk

The SPRINT study

Who this study is aimed at?

Adults who have previously been admitted to an acute mental health ward. Friends or relatives of these adults, who are willing to share further information with consent.

Who can’t take part?

Exclusion criteria include patients under the age of 18 years, over the age of 65 years and/or having no history of being a psychiatric inpatient.

Study summary

There has been little research into how common problems with social communication are in people who have been admitted to mental health wards, as well as their physical and mental health needs.

A research team at the University of Leicester has launched a study to learn more about these issues.

Study visits

The study will involve completion of autism-based questionnaire tests and an interview process

Services taking part

Limbrick Health Centre

Who to contact

Study Co-ordinator Hannah Gower

How to contact

Tel: 0114 2716315

Email: hannah.gower@shsc.nhs.uk

Hearing nasty voices: Developing new ways to measure the experience

Who this study is aimed at?

  1. Currently experience voices which threaten then or put them down (nasty voices)
  2. These voices must occur at least once per week
  3. Be aged 16 or older
  4. Be in contact with mental health services

Study summary

Hearing voices is one of the most common symptoms of schizophrenia. We aim to learn why some patients listen to and believe the content of distressing voices. This will enable the later development of psychological therapies which enable patients to disengage from distressing voice content.

Study visits

  1. A questionnaire that measures the amount that people i) Believe the things that nasty voices say; ii) Listen to nasty voices.
  2. A questionnaire that measures the reasons why people listen and believe nasty voices.    

Services taking part

Limbrick Health Centre

Who to contact

Dr Andrew Horan, Local Principal Investigator, Recovery Service North

How to contact

Email: Andrew.Horan@shsc.nhs.uk

Tel: 0114 271 6217

PREFER - Patient preferences for voice-hearing therapies

Who this study is aimed at?

You can take part if you are 16 years and over and have heard voices for at least six months. We would like to invite the following groups of people to take part: people who have and have not had psychological therapy in the past, people who do and do not have a mental health diagnosis.

Study summary

There are lots of different types of psychological (talking) therapies for the experience of hearing distressing voices. However, there hasn’t been any research about patient preferences for these therapies. We would like to find out more about your preferences, for example:

  • Practical things - like where you think therapy should take place. 
  • Techniques - what you think therapy should involve.
  • Outcomes - what you think therapy should focus on and try to help with. 

We want to be able to publish this information in scientific and healthcare journals and conferences. This will help clinicians and researchers to develop and offer therapies that better match with the patients’ preferences.    

Study visits

The study involves completing some questionnaires. These will include questions:

  • About you
  • About your voice-hearing and mental health experiences
  • About your therapy preferences
  • About and your thoughts and feelings about your life and future

Who to contact

Research Development Unit

How to contact

research.developmentunit@shsc.nhs.uk

BAN2401 - A Placebo-Controlled, Double-Blind, Parallel-Group, 18-Month Study with an Open-Label Extension Phase to Confirm Safety and Efficacy of BAN2401 in Subjects With Early Alzheimer’s Disease

Who this study is aimed at?

Patients with a diagnosis of Alzheimer’s disease between the age of 50 to 90

Study summary

Many people may find their memory changes as they age. For most, it is a natural part of aging. For some however, it could be an indication of something more serious. For some, it could be Alzheimer’s Disease.

St Pancras Clinical Research is conducting a trial of an investigational drug for early stage Alzheimer’s, if you would like more information, please contact St Pancras Clinical Research at www.stpancrasclinicalresearch.com

Services taking part

Memory Service 

Who to contact

Amanda Bennett, Research Nurse

How to contact

Amanda.bennett@shsc.nhs.uk

The COVID-19 Resilience Project

Who this study is aimed at?

NHS clinical staff whose job role involves direct patient contact and care provision will be eligible. Participants working in England the context of acute non-specialist NHS Trusts, acute specialist NHS Trusts, mental health NHS Trusts, NHS community care providers (including NHS Trusts, social enterprises and limited companies) and ambulance trusts will be eligible. Professionals in regional and special NHS Boards in Scotland, Local Health Boards and NHS Trusts in Wales, Health and Social Care Trusts in Northern Ireland and GP practices across the UK will be also eligible if job role involves direct patient contact and care provision.

Who can't take part

Those unwilling to give consent to participate, NHS non-clinical staff (e.g. administrators), Non-NHS staff, Public volunteers for the NHS.

Study summary

Participants (i.e. NHS clinical staff) will be invited to complete an online battery of self-report questionnaires exploring impact of COVID-related stressors on mental health outcomes, including anxiety, depression, post-traumatic stress, and burnout, and to investigate the effect of psychological markers of risk and resilience that might exacerbate or buffer the impact of COVID-related stressors on mental health. Participants will be invited to re-complete questionnaires after 4, 8, and 12 months. A subsample of participants will also be invited to take part in a qualitative interview to further explore their experiences

Services taking part

All clinical staff whose job role involves direct patient contact and care provision will be eligible.

How to contact

Click here.

Find out more

To find out more information, click here.

Psychological impact of the Coronavirus (COVID-19) pandemic and experience: An international survey

Who this study is aimed at?

Anybody.

Who can’t take part?

People under 16 years of age.

Study summary

The aim of this survey is to better understand how the Coronavirus and the restrictions necessary to prevent its spread are impacting on our day to day lifestyle. We hope to find out what is helpful for people during this time and also what may be causing some people to be affected more than others in terms of their wellbeing.

Study visits

One off survey.

Who to contact

Dr Peter Phiri

How to contact

peter.phiri@southernhealth.nhs.uk

Take part

To take part in the study, click here.

Study to test how well a new vaccine works against COVID-19

Who this study is aimed at?

Health and social care workers who live in a Sheffield postcode and are working in areas caring for people at higher risk of having or being exposed to COVID-19.

Who can’t take part?

People under 18 years of age or over 55 years of age, people who have tested positive for COVID-19, those who are pregnant, intending to become pregnant, or breastfeeding during the study and those who have previously taken part in a trial with an adenoviral vaccine or received any other Coronavirus vaccines.

Study summary

Sheffield Teaching Hospitals and the University of Sheffield are involved in a number of national and local COVID-19 research studies to understand and support how we manage, treat and prevent infection.

One of the trials the Trust is about to start is a large multi-site study being led by Oxford University regarding the use of a potential vaccine.

This study involves at least 18 sites in the UK including Sheffield Teaching Hospitals and will enable them to assess how well people involved in care and healthcare delivery might be protected against COVID-19 with the new ChAdOx1 nCoV-19 vaccine. The study will also provide valuable information on safety aspects of the vaccine and how well participants’ immune systems respond to immunisation with the vaccine.

Click here and carefully read all of the information about the study. This is a research study and so there are potential risks to taking part as well as benefits. It is important you consider the impact on you and your family members of taking part before volunteering.

Study visits

If you are accepted for the trial you will receive one or two doses of either the ChAdOx1 nCoV-19 or a licensed vaccine (MenACWY) which prevents meningococcal infection and will be used as a ‘control’ for comparison.

Up to 8 blood tests will be taken over the course of a year to check if there are any problems and to look at your immune responses to the vaccine.

For some participants there will be a diary to complete for up to 28 days following vaccination

There is a weekly questionnaire that monitors your and members of your households exposure to COVID-19

In order to monitor for exposure to COVID-19 in those who do not develop symptoms you may be asked to perform weekly nasal swabs or saliva collection.

The study will take a year to complete.

Who to contact

Clinical Research and Innovation Office at Sheffield Teaching Hospitals NHS Foundation Trust

How to contact

sth.cov002@nhs.net

Find out more

To find out more about this study, click here.

Understanding the Psychological and Moral Distress, Support and Coping Mechanisms among NHS Staff during COVID-19 Pandemic

Who this study is aimed at?

Individuals working within the NHS who has recently worked for the NHS during the COVID-19 pandemic

Who can’t take part?

People who are not NHS workers.

Study summary

As our NHS heroic staff you are under unprecedented levels of stress, which are likely adversely impacting your health and well-being. In order that we can better understand how to support you during such times, and ultimately improve your health and well-being, we would like to ask for your input into our research by answering the questions within a survey. These ask about your psychological and moral distress level, your perception of the importance of different types of support and coping mechanisms during COVID-19 pandemic working conditions.

Study visits

One off questionnaire.

Who to contact

Alison Stubbs

How to contact

Alison.Stubbs@shsc.nhs.uk

Take part

To take the survey, click here.

COVIDA study on the impact of COVID-19 outbreak the mental health of health workers

Who this study is aimed at?

NHS and non-NHS health workers.

Who can’t take part?

People who are not NHS or non-NHS health workers.

Study summary

Questionnaire on the impact of the COVID-19 outbreak on the mental health of participants. The nationwide study will allow us to understand the severity of this impact, the factors associated with a worse or resilience response; and importantly how the impact on mental health changes over time as the COVID-19 crisis evolves.

Study visits

One off questionnaire.

Who to contact

Alison Stubbs

How to contact

Alison.Stubbs@shsc.nhs.uk

Take part

To take the survey, click here.

Evaluating the Impact of Minimum Unit Pricing in Scotland on Harmful Drinkers

Who this study is aimed at?

Service users who are seeing treatment services in relation their alcohol use.

Who can’t take part?

Individuals with cognitive impairment or unable to understand and speak English.

Study summary

One off interview with a researcher.

Study visits

One.

Services taking part

Sheffield Treatment and Recovery Team.

Who to contact

Dr Olawale Lagundoye

How to contact

olawale.lagundoye@shsc.nhs.uk

DLB Genetics - Detecting susceptibility genes for dementia with Lewy bodies

Who this study is aimed at?

  • People who have probable dementia with lewy bodies.
  • Two or more core clinical features without biomarkers or one clinical feature with biomarkers
  • A willingness to provide a blood or saliva sample for genetic analysis
  • White European ethnicity
  • People who have an available study partner

Who can’t take part?

  • People who do not have parkinsonism at mild and moderate stages of dementia.
  • Diagnosis of Parkinson disease dementia (PDD)
  • Diagnosis of substance misuse or substance dependence
  • Learning disability
  • Major psychiatric illness

Study summary

This study involves:

  • a trained research assistant or research nurse visiting you either at home or at a local clinic. This visit will last around two hours
  • answering questions about yourself and taking part in a memory test
  • providing a blood sample
  • inviting a family member or friend to help by answering some questions about your diagnosis.

Study visits

One visit of approximately two hours.

Services taking part

Older adult services at Edmund Road and the Longley Centre.

Who to contact

Dr Aparna Mordekar

How to contact

Aparna.mordekar@shsc.nhs.uk

Find out more

To find out more about this study, click here.

Evaluating Mental Health Decision Units in acute care pathways

Who this study is aimed at?

Service users who have recently had their first visit to the Decisions Unit.

Who can’t take part

Service users whose visit to the Decision Unit is not their first.

Study summary

This study involves answering six questions about quality of life when and again nine months later.  Researchers will also ask our professionals how much you have used services, and which services you have used for your mental health in the nine months before and after your first admission to the Decisions Unit.

There is also an option to take part in two in-depth interviews about your experiences of crisis care in mental health services. If so, the first interview will be within a fortnight of you leaving the Decisions Unit and the second interview will be nine months later.

Study visits

One to two. The second questionnaire can be completed by post, with an option for a further two visits if you choose to take part in the additional in-depth interviews.

Services taking part

Decisions Unit.

Who to contact

Dr Raihan Talukdar

How to contact

raihan.talukdar@shsc.nhs.uk

Share this

Was this page useful?